Group 3: Anne Skov-Johannessen s184330, Dea F. Skipper, Helene B. L. Petersen s194699, Johanne B. Overgaard s194691 and Rebecca C. Grenov
The leading cause of death in HIV-infected individuals.
Weakened immune system
Limits sensitivity of diagnosis of TB
Support vector machine to find 251-gene signature
Genes involved in Immunological, Infectious and Inflammatory Disease
Limits sensitivity of diagnosis of TB
Our aim:
Explore genes with a significant expression enriched in HIV with TB co-infection
Compare with the 251-gene signature found with the SVM model
Keep it clean and tidy:
Select variables
Mutate variables
Handle key-variable
Handle replications

Normalization - minimize technical variability
Log transformation - stabilize variance, reduce skewness
Quantile Normalization:
First PC explains 15% of the variance
31 PCs needed to explain 90% of variance
Forest plot
Volcano plot